The research and technological development activities, carried out through coordination and participation in numerous European, national, and regional industrial research and experimental development projects, focus on information processing systems, with significant applications in various domains, particularly in the digital health sector. The main areas of interest include: software architectures for complex systems, ultimately promoting interoperability between heterogeneous information systems in compliance with industry technical standards and personal data protection regulations; the organization of structured and unstructured data using big data management and analytics approaches; the application of cybersecurity techniques to protect critical networked infrastructures; and the management of IT platforms enabling the creation of distributed research infrastructures. Since 2009, he has actively participated in institutional Boards on the Electronic Health Record (EHR) for the implementation of current regulations, with a particular focus on formalising business processes, technical rules for interoperability of IT platforms, and data representation methods. He has co-authored over 100 scientific articles and technical reports published in international and national journals, conference proceedings, books, and institutional series. He serves as a reviewer for European and national research projects, a member of the editorial and program committees of several international journals, conferences, and workshops, and has co-supervised numerous dissertations. Since 2012, he has been an adjunct professor of computer science courses in Engineering programs at the University of Naples “Federico II” and other universities. He is a member of the Board of Directors of HL7 Italy, the UNI Control Room on Digitalisation, and the UNINFO Commission on Medical Informatics. He is also a co-founder of the Italian Scientific Society of Biomedical Informatics and a former member of the Board of Directors of the Italian Association of Telemedicine and Medical Informatics.