skip to Main Content
Involved Laboratories:

Translational Bioinformatics;

Selected Publications:

Fiannaca, M. La Rosa, L. Lapaglia, R. Rizzo, A. Urso. Analysis of miRNA expression profiles in breast cancer using biclustering. BMC Bioinformatics, vol.16 (Suppl.4) p. S7, 2015

Mirco MIcroRna In Oncology Clinic

The main objective of the project is the development of an integrated approach that allows evaluating expression profiles of a set of selected miRNA  in order to combine the results with the ones obtained by means of traditional diagnostic procedures. This way it is possible to obtain an individual genetic “signature” that can be used to implement new measures for the diagnosis, the prognosis and personalized treatment of several human cancer diseases, such as breast, prostate, lung cancer. This approach should bring to the production of biochips, customized according to population and disease, that would be validated over a series of biological samples, extracted from biobanks of peripheral blood and tissues) both tumoral and healthy. Data have been analysed by means of mathematical models and innovative bioinformatics tools. During the project, differential expression analysis of miRNAs has been carried out in blood and tissue samples of healthy patients and patients affected by breast cancer subject to different dietary treatments. We identified clusters of differentially expressed miRNA related to classes of patients, both healthy and not, subject to different dietary treatments and moreover, we identified gene targets, corresponding to miRNA clusters, that have been functionally enriched. This way it is possible to discover relationships among miRNA, targets and pathways related to a characterized group of patients. Finally, we designed a SQL database in order to store and make available patients data, including raw RNA-seq data of both mRNA and miRNA, together with histologic values of tissues, the clusters of differentially expressed miRNA and potential biomarkers

STRAT DATE APRIL 2014
END DATE DECEMBER 2015

Back To Top