The project analyzed new technologies for the creation of instruments for personalized diagnosis and therapy through the sequencing of mutations that cause tumors and multifactorial genetic diseases. High-throughput (HT) DNA sequencing instrumentation was developed using proprietary technologies. An innovative robotic platform and its related interface for remote management, which governs the apparatus for DNA extraction, PCR amplification, and HT sequencing, was designed and implemented. Furthermore, DNA sensors based on chemiluminescence detection were designed; these sensors were developed for second-generation, single-use, miniaturized, and low-cost instruments.

ICAR carried out activities for the development of innovative interfacing techniques between biomolecular research and bioengineering.

🔬 Work Packages / Activities performed by ICAR-CNR:

• WP 10.1: Remote control and planning for the mechatronic platform

• WP 10.3: Remote management of sequencer data analysis on the distributed web portal/repository

• WP 11.1: Development of software for robotic integration and data acquisition